Mesenchymal stem cells (MSCs) are adult stem cells with stromal functions and more limited differentiation capacity than pluripotent stem cells. However, due to their clinical safety and immunomodulatory potential, they have quickly become a cell type with great potential for regenerative medicine and immunotherapies. Typically, MSCs are isolated from tissues such as the umbilical cord, bone marrow, and adipose tissue. Instead, we are investigating how to obtain them by differentiating them from pluripotent stem cells. On the other hand, MSCs are capable of secreting lipid vesicles that contain proteins, mRNAs and miRNAs that, when in contact with other cells, can transmit the same regenerative and immunomodulatory message to them. In our laboratory we work with MSCs derived from pluripotent cells and their exosomes, studying the various mechanisms by which these can contribute to designing new regenerative therapies.
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