I lead a dynamic and multidisciplinary research group focused on cardiac regeneration using human pluripotent stem cells. Our goal is to decipher mechanisms that enable human heart regeneration and develop innovative therapeutic strategies.
My current team:
We study the differentiation of human pluripotent stem cells into cardiomyocytes, with particular emphasis on maturation processes that transform cardiomyocytes from a fetal to a postnatal phenotype. This transition is key to developing relevant models of the adult human heart.
We investigate strategies to induce proliferation of mature cardiomyocytes through the expression of specific factors using advanced methodologies such as baculovirus transduction. In parallel, we develop specialized tools to accurately quantify proliferation rates, overcoming the technical challenges associated with the polynucleation and polyploidy characteristic of these cells.
My laboratory integrates cutting-edge technologies:
Ariel Waisman
microPublication biology, 2025
Ariel Waisman, Federico Sevlever, Denisse Saulnier, Marcos Francia, Renata Blanco, Guadalupe Amín, Antonella Lombardi, Celeste Biani, María Belén Palma, Agustina Scarafía, Joaquín Smucler, Alejandro La Greca, Lucía Moro, Gustavo Sevlever, Alejandra Guberman, Santiago Miriuka
Scientific Reports, 2024
Automatic and unbiased segmentation and quantification of myofibers in skeletal muscle
Ariel Waisman, Alessandra Marie Norris, Martín Elías Costa, Daniel Kopinke
Scientific Reports, 2021
Ariel Waisman, Alejandro La Greca, Alan M Möbbs, María Agustina Scarafía, Natalia L Santín Velazque, Gabriel Neiman, Lucía N Moro, Carlos Luzzani, Gustavo E Sevlever, Alejandra S Guberman, Santiago G Miriuka
Stem Cell Reports, 2019
Ariel Waisman, Federico Sevlever, Martín Elías Costa, María Soledad Cosentino, Santiago G Miriuka, Alejandra C Ventura, Alejandra S Guberman
Scientific Reports, 2019
Inhibition of cell division and DNA replication impair mouse-naive pluripotency exit
Ariel Waisman, Camila Vazquez Echegaray, Claudia Solari, María Soledad Cosentino, Iain Martyn, Alessia Deglincerti, Mohammad Zeeshan Ozair, Albert Ruzo, Lino Barañao, Santiago Miriuka, Ali Brivanlou, Alejandra Guberman
Journal of molecular biology, 2017